Parkinson’s disease – Symptoms and treatment options

Parkinson’s disease – Symptoms and treatment options

Roman Short

Parkinson’s is a progressive neurological condition that mostly affects people above 60. The symptoms start showing gradually, but they can progress and lead to severe complications if not treated on time. The disease can start with a small tremor in one hand and eventually slow down an individual’s movement and significantly affect their quality of life. Parkinson’s disease does not have a cure yet, but treatment can help manage the symptoms. Read on to know more about Parkinson’s treatment in detail.

Symptoms of Parkinson’s disease
The signs and symptoms of this disease can vary from one person to another. The symptoms usually begin on one side of the body and gradually affect the other side as well. Additionally, the condition causes the symptoms to worsen with time. One should watch out for the following Parkinson’s symptoms:

  • Tremors
    Constant tremors, which usually start in the hands and arms, are the primary sign of Parkinson’s disease. A patient’s hand may tremble even when they are at rest.
  • Muscle stiffness
    Muscle stiffness can occur in any part of the body and can limit an individual’s range of motion due to muscle pain. The disease can make one’s steps shorter and make it difficult for them to stand from a seating position.
  • Poor posture and balance
    A patient may start hunching to balance their body weight, which could lead to poor posture.
  • Speech impairment
    Due to the lack of coordination between the brain and muscles, a Parkinson’s patient might start slurring or hesitate while talking. This is because the condition impairs nerve cells in the brain.

Treatment options for Parkinson’s disease
After reviewing the patient’s signs and symptoms and running some tests, the doctor may diagnose Parkinson’s and determine its progress. The recommended course of treatment depends on the severity of the condition. For patients in the early stages of the disease, medication and a healthy lifestyle can help treat the symptoms. On the other hand, doctors may suggest surgery in severe cases.

Medication

  • Levodopa
    It is a dopamine precursor that helps treat the symptoms of Parkinson’s disease. It is often combined with carbidopa to allow levodopa to reach the brain and prevent nausea and other side effects. This medication is also available in other forms, one of which allows patients to inhale the carbidopa-levodopa combination to manage the symptoms. Another form of this treatment for Parkinson’s disease is infused levodopa and carbidopa, which is administered through a feeding tube that delivers it directly into the small intestine.
  • Dopamine agonists
    This is another medication used to treat the symptoms of Parkinson’s. While these medicines are not converted into dopamine, they mimic the effects of dopamine in the brain. The effects of this Parkinson’s treatment last longer than levodopa therapy, but it isn’t as effective. Some common dopamine agonists are rotigotine (Neupro), pramipexole (Mirapex), and ropinirole (Requip).
  • MAO B inhibitors
    These medications inhibit the brain enzyme monoamine oxidase B (MAO B) to help prevent dopamine breakdown in the brain. Selegiline (Zelapar), rasagiline (Azilect), and safinamide (Xadago) are some MAO B inhibitors. These medicines can cause side effects like insomnia, headaches, and nausea.
  • Catechol O-methyltransferase (COMT) inhibitors
    These types of medications block the enzyme that breaks down dopamine, prolonging the effects of levodopa therapy. The primary medications in this category are entacapone (Comtan) and opicapone (Ongentys). That said, these medications can cause side effects like involuntary movements, which result from an enhanced levodopa effect.
  • Anticholinergics
    These are another class of medications prescribed for Parkinson’s treatment, especially to manage tremors. However, they can lead to side effects like hallucinations, confusion, impaired memory, constipation, and impaired urination.
  • Amantadine
    This medication is an effective treatment method for short-term relief from mild, early-stage Parkinson’s disease, but it is also prescribed along with carbidopa-levodopa therapy to manage involuntary movements in people with advanced-stage Parkinson’s.
    While one can manage mild to moderate Parkinson’s disease with the help of medication, the advanced stages of this illness need more assistance. Advanced Parkinson’s may require a surgical procedure and a healthy lifestyle.

Surgery
Deep brain stimulation is a surgical procedure that involves placing electrodes into a part of the brain, and they are connected to a generator implanted in the chest. The connector in the chest sends electrical pulses to the brain and helps manage the symptoms of Parkinson’s disease. This treatment is recommended for people with Parkinson’s disease who show unstable responses to medication. That said, surgery is associated with risks like brain hemorrhage, stroke, or infection.

Lifestyle choices that help manage Parkinson’s symptoms

  • An active lifestyle
    Parkinson’s disease is associated with a lack of coordination between the limbs and the brain and poor balance. These, in turn, affect movement, hampering a patient’s daily routine. One must adopt an active lifestyle to improve their range of motion and balance. This can include taking up activities like gardening, household chores, walking, and mild exercises approved by a therapist. Leading an active lifestyle stimulates the brain and reduces feelings like anxiety. Yoga, meditation, Tai Chi, massage, and pet therapy are among the other forms of activities one can take up.
  • Healthy eating
    While there’s no specific diet or particular foods that can help manage the symptoms of Parkinson’s, one can start with eating clean. This includes eating home-cooked meals and including fresh fruits, salads, and smoothies in the regular diet. Eating out of the freezer is not an option for people combating a long-term illness. In fact, one must avoid packaged juices and foods as they contain preservatives and artificial colors. Additionally, one should ensure that their daily diet has a good balance of fiber, carbohydrates, saturated fats, and proteins.
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